PTPRM

PTPRM

Identifiers Symbols PTPRM; PTPRL1; R-PTP-MU; RPTPM; RPTPU; hR-PTPu External IDs OMIM: 176888 MGI: 102694 HomoloGene: 37694 ChEMBL: 4661 GeneCards: PTPRM Gene EC number 3.1.3.48

Gene Ontology
Molecular function • protein tyrosine phosphatase activity
• transmembrane receptor protein tyrosine phosphatase activity
• protein binding
• cadherin binding
Cellular component • cytoplasm
• integral to plasma membrane
• cell-cell junction
• cell-cell adherens junction
• lamellipodium
• perinuclear region of cytoplasm
Biological process • negative regulation of endothelial cell proliferation
• protein dephosphorylation
• homophilic cell adhesion
• signal transduction
• negative regulation of endothelial cell migration
• retina layer formation
• negative regulation of angiogenesis
• neuron projection development
• retinal ganglion cell axon guidance
• peptidyl-tyrosine dephosphorylation
• response to drug
• positive regulation of vasodilation
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5797 19274 Ensembl ENSG00000173482 ENSMUSG00000033278 UniProt P28827 P28828 RefSeq (mRNA) NM_001105244 NM_008984 RefSeq (protein) NP_001098714 NP_033010 Location (UCSC) Chr 18:
7.57 – 8.41 Mb Chr 17:
66.67 – 67.35 Mb PubMed search

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.

Read more about PTPRM:  Function, Structure, Homophilic Binding, Tyrosine Phosphatase Activity, Cadherin-dependent Adhesion, Endothelial Cell Adhesion, Interactions