PSB can stand for:
- Please see below
- Organisations
- Brazilian Socialist Party (Brazilian: Partido Socialista Brasileiro)
- Pacific Symposium on Biocomputing, an annual scientific meeting
- Penn, Schoen & Berland, a market research firm
- Phosphate Solublising Bacteria
- Pine shoot beetle, a bark beetle native to Afro-Eurasia
- Presidential Service Badge, a badge of the US military issued to those who serve the President
- Proton Synchrotron Booster, a synchrotron at CERN
- PSB Academy, a private school mainly located in Singapore
- PSB Speakers, a Canadian loudspeaker company
- Public Security Bureau, the name for police station in Mainland China
- Public Service Broadcasting, media outlets funded mostly by the public
- Punjab & Sind Bank,a major bank in Northern India
- Science and nature
- Medicine
- Protected specimen brush
- Peak serum bilirubin
- Prostate saturation biopsy
- Proximal small bowel
- Technology
- PhotoShop Big (.PSB), a file format used by Adobe Systems Photoshop Software
- PlayStation.Blog, the official PlayStation blog
- Power Signal Box, a British type of railway signalling centre
- Program Specification Block, used in the IBM database IBM Information Management System
- Literate and music
- Pet Shop Boys, a British pop duo
- Plus-Tech Squeeze Box, a Japanese electronic music band
- Polski Słownik Biograficzny, a Polish encyclopedia
- Other
- Pearl S. Buck, an American Nobel Laureate
- Perpetual subordinated bond, a financial term
- Poplar Street Bridge, a bridge across the Mississippi River
- Prawn sandwich brigade, emotionally detached football fans