Proteolysis and Diseases
Abnormal proteolytic activity are associated with many diseases. In pancreatitis, leakage of proteases and their premature activation in the pancreas results in the self-digestion of the pancreas. People with diabetes mellitus may have increased lysosomal activity and the degradation of some proteins can increase significantly. Chronic inflammatory diseases such as rheumatoid arthritis may involve the release of lysosomal enzymes into extracellular space which break down surrounding tissues. Abnormal proteolysis and generation of peptides that aggregate in cells and their ineffective removal may result in many age-related neurological diseases such as Alzheimer.
Other diseases linked to aberrant proteolysis include muscular dystrophy, degenerative skin disorders, respiratory and gastrointestinal diseases, and malignancy.
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