Tyrosine-specific Protein Kinases
Tyrosine-specific protein kinases (EC 2.7.10.1 and EC 2.7.10.2) phosphorylate tyrosine amino acid residues, and like serine/threonine-specific kinases are used in signal transduction. They act primarily as growth factor receptors and in downstream signaling from growth factors; some examples:
- Platelet-derived growth factor receptor (PDGFR)
- Epidermal growth factor receptor (EGFR)
- Insulin receptor and insulin-like growth factor 1 receptor (IGF1R)
- Stem cell factor (SCF) receptor (also called c-kit, see the article on gastrointestinal stromal tumor).
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