Use and Importance of Protein Families
As the total number of sequenced proteins increases and interest expands in proteome analysis, there is an ongoing effort to organize proteins into families and to describe their component domains and motifs. Reliable identification of protein families is critical to phylogenetic analysis, functional annotation, and the exploration of diversity of protein function in a given phylogenetic branch. The Enzyme Function Initiative (EFI) is using protein families and superfamilies as the basis for development of a sequence/structure-based strategy for large scale functional assignment of enzymes of unknown function.
The algorithmic means for establishing protein families on a large scale are based on a notion of similarity. Most of the time the only similarity we have access to is sequence similarity.
Read more about this topic: Protein Families
Famous quotes containing the words importance, protein and/or families:
“Coming together again after a long day apart can be an experience where joy, relief, anger, and fatigue are all present in different degrees both for the parent and for the child. Because of their importance in marking the resumption of direct contact, reunions deserve as much attention and care as separations to enhance the relationship between parent and child.”
—Alicia F. Lieberman (20th century)
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)
“The man who promised to reinforce American families is now eager to pull the plug on Big Bird and Barney.”
—Leslie Harris, U.S. political activist. As quoted in Newsweek magazine, p. 23 (December 19, 1994)