PPE may stand for:
- Palmoplantar erythrodysesthesia syndrome
- Park Place Entertainment (now part of Caesar's Entertainment)
- European People's Party
- European People's Party (European Parliament group)
- PCBoard Program Executable
- Personal protective equipment
- Philosophy, Politics and Economics, an academic degree
- Polyphenyl ether
- Porcine proliferative enteropathy (see enteropathy)
- Power Processor Element
- Property, plant and equipment
- Puerto Peñasco International Airport, Mexico