PPB can stand for:
- Production-possibility boundary, a graph that shows the different quantities of two goods that an economy could efficiently produce with limited productive resources
- Party political broadcast, a type of political programming in the United Kingdom
- parts per billion, a unit of concentration
- Portland Police Bureau, a police agency for the city of Portland
- Partido Progressista Brasileiro, former name of Progressive Party of Brazil
- Pirate Party of Brazil
- Pirate Party of Belgium
- Pirate Party of Bulgaria
- Pleuropulmonary blastoma, a type of lung cancer
- Plasma protein binding, a factor contributing to the efficacy of a pharmacological agent