PMS2

PMS2

Identifiers Symbols PMS2; HNPCC4; PMS2CL; PMSL2 External IDs OMIM: 600259 MGI: 104288 HomoloGene: 450 GeneCards: PMS2 Gene

Gene Ontology
Molecular function DNA binding
single-stranded DNA binding
endonuclease activity
protein binding
ATP binding
ATPase activity
single base insertion or deletion binding
MutSalpha complex binding
Cellular component nucleus
mismatch repair complex
MutLalpha complex
Biological process ATP catabolic process
mismatch repair
reciprocal meiotic recombination
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
response to drug
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5395 18861 Ensembl ENSG00000122512 ENSMUSG00000079109 UniProt P54278 A4QPD7 RefSeq (mRNA) NM_000535 NM_008886 RefSeq (protein) NP_000526 NP_032912 Location (UCSC) Chr 7:
6.01 – 6.05 Mb Chr 5:
143.91 – 143.94 Mb PubMed search

Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene.

Read more about PMS2:  Function, Mutations, Interactions

Other articles related to "pms2":

PMS2 - Interactions - Interactions Involving P53 and P73
... PMS2 has also been shown to interact with p53 and p73 ... In the absence of p53, PMS2-deficient and PMS2-proficient cells are still capable of arresting the cell cycle at the G2/M checkpoint when treated with ... Cells that are deficient in p53 and PMS2, exhibit increased sensitivity to anticancer agents ...