Early Life
De Smet was born in Dendermonde, in what is now Belgium. He first came to the United States with eleven other Belgian Jesuits in 1821 to begin his novitiate at White Marsh, a Jesuit estate near Baltimore, Maryland. Part of the complex survives today as Sacred Heart Church in Bowie.
De Smet and five other Belgian novices, led by Charles Van Quickenborne, moved to Florissant, Missouri, at the invitation of bishop Dubourg. Several academic institutions were immediately founded, among which the St. Regis Seminary where De Smet had his first contacts with indigenous boys. After further studies, he was ordained priest on 23 September 1827. Until 1830, he learned about Indian customs and languages as a prefect at the seminary. In 1833 he had to return to Belgium due to health problems. It was 1837 before he could return to Missouri.
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