Periodic paralysis (also known as Myoplegia paroxysmalis familiaris) is a group of rare genetic diseases that lead to weakness or paralysis (rarely death) from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind. The underlying mechanism of these diseases are malfunctions in the ion channels in skeletal muscle cell membranes that allow electrically charged ions to leak in or out of the muscle cell, causing the cell to depolarize and become unable to move (a channelopathy).
The symptoms of periodic paralysis can also be caused by hyperthyroidism, and are then labeled thyrotoxic periodic paralysis; however, if this is the underlying condition there are likely to be other characteristic manifestations, enabling a correct diagnosis.
Read more about Periodic Paralysis: Types, Diagnosis, Treatment, Prognosis
Famous quotes containing the word periodic:
“It can be demonstrated that the child’s contact with the real world is strengthened by his periodic excursions into fantasy. It becomes easier to tolerate the frustrations of the real world and to accede to the demands of reality if one can restore himself at intervals in a world where the deepest wishes can achieve imaginary gratification.”
—Selma H. Fraiberg (20th century)