Osea or OSEA may refer to:
- Osea Island, an inhabited island in the estuary of the River Blackwater, Essex, East England, or
- Cyclone Osea, the second of seven cyclones to affect French Polynesia during the 1997-98 South Pacific cyclone season;
- Osea Sadrau (born 1986), Fijian rugby league player for AS Carcassonne in the Elite One Championship;
- Osea Vakatalesau (born 1986), Fijian football striker playing for the Fiji national football team; or the
- Ontario Sustainable Energy Association (OSEA), a non-profit organization supporting the growth of renewable energy projects in Ontario, Canada
- Osea, a fictional country in Ace Combat 5: The Unsung War
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