OFM can refer to:
- Office of Foreign Missions, part of the US Department of State
- OFM (Band), UK alternative indie/rock band
- OFM, Inc, a furniture manufacturer and distributor in North Carolina
- OFM (South Africa), a radio station in Bloemfontein, South Africa
- Online football manager, online game
- Oracle Fusion Middleware
- Orange Factory Music, music production team
- Ordo Fratrum Minorum (Order of Friars Minor), a Franciscan religious order
- Orthodox file manager
- Our Favorite Moments, an online personal archiving system
- Output feedback mode, a way of using a block cipher as a stream cipher