ODB can refer to:
- the IATA airport code of Córdoba Airport
- Ol' Dirty Bastard (1968–2004), American rapper and founding member of the Wu-Tang Clan
- ODB (wrestler) (born 1978), ring name of American professional wrestler Jessica Kresa
- ODB (C++), an object-relational mapping (ORM) system for C++ programming language
- ODB++, a CAD-to-CAM data exchange format used in the design and manufacture of electronic devices
- David Baker (poker player, born 1972) (born 1972), American poker player
- Omniscient Debugger, a Java programming-language debugger
- Oxford Dictionary of Byzantium
.odb: OpenDocument Format (ODF) database - file-extension used on database and connection files- Our Daily Bread, Christian devotional booklets produced by RBC Ministries