Pill Colors
Nuke has a second heart, and takes different colored pills to produce different bodily effects. Nuke's pill colors are: red, for increased adrenaline; white, to bring him down; and blue, to keep him docile between missions.
It was originally stated that the red pills Nuke took affected his adrenal glands, sending him into his bloodthirsty rages. The Wolverine: Origins series retconned this, stating instead that these pills are placebos, suggesting that Nuke lives in a constant state of increased adrenaline, but doesn't know it. The pills, therefore, trigger his violent behavior, but the effect is psychosomatic.
Read more about this topic: Nuke (Marvel Comics)
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