Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds. In this type of reaction, a nucleophile - such as an alcohol, amine, or enolate - displaces the leaving group of an acyl derivative - such as an acid halide, anhydride, or ester. The resulting product is a carbonyl-containing compound in which the nucleophile has taken the place of the leaving group present in the original acyl derivative. Because acyl derivatives react with a wide variety of nucleophiles, and because the product can depend on the particular type of acyl derivative and nucleophile involved, nucleophilic acyl substitution reactions can be used to synthesize a variety of different products.
Read more about Nucleophilic Acyl Substitution: Reaction Mechanism, Reactivity Trends, Reactions of Acyl Derivatives
Other articles related to "nucleophilic acyl substitution, nucleophilic, acyl":
... acids are not especially reactive towards nucleophilic substitution, though they can be converted to other acyl derivatives ... oxonium ion 2 is activated towards nucleophilic attack and has a good leaving group, setting it apart from a normal carboxylic acid ...
Famous quotes containing the word substitution:
“To play is nothing but the imitative substitution of a pleasurable, superfluous and voluntary action for a serious, necessary, imperative and difficult one. At the cradle of play as well as of artistic activity there stood leisure, tedium entailed by increased spiritual mobility, a horror vacui, the need of letting forms no longer imprisoned move freely, of filling empty time with sequences of notes, empty space with sequences of form.”
—Max J. Friedländer (1867–1958)