Nucleophilic Acyl Substitution

Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds. In this type of reaction, a nucleophile - such as an alcohol, amine, or enolate - displaces the leaving group of an acyl derivative - such as an acid halide, anhydride, or ester. The resulting product is a carbonyl-containing compound in which the nucleophile has taken the place of the leaving group present in the original acyl derivative. Because acyl derivatives react with a wide variety of nucleophiles, and because the product can depend on the particular type of acyl derivative and nucleophile involved, nucleophilic acyl substitution reactions can be used to synthesize a variety of different products.

Read more about Nucleophilic Acyl SubstitutionReaction Mechanism, Reactivity Trends, Reactions of Acyl Derivatives

Other articles related to "nucleophilic acyl substitution, nucleophilic, acyl":

Nucleophilic Acyl Substitution - Reactions of Acyl Derivatives - Carboxylic Acids
... Carboxylic acids are not especially reactive towards nucleophilic substitution, though they can be converted to other acyl derivatives ... The resulting oxonium ion 2 is activated towards nucleophilic attack and has a good leaving group, setting it apart from a normal carboxylic acid ...

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