Limitations
One of the main drawbacks of the Henry Reaction is the potential for side reactions throughout the course of the reaction. Aside from the reversibility of the reaction (Retro-Henry) which could prevent the reaction from proceeding, the β-nitro alcohol has the potential to undergo dehydration, and for sterically hindered substrates it is possible that a base catalyzed self-condensation (Cannizaro reaction) could occur. A general scheme of the Cannizzaro reaction is depicted below.
Read more about this topic: Nitroaldol Reaction
Famous quotes containing the word limitations:
“To note an artists limitations is but to define his talent. A reporter can write equally well about everything that is presented to his view, but a creative writer can do his best only with what lies within the range and character of his deepest sympathies.”
—Willa Cather (18761947)
“Growing up means letting go of the dearest megalomaniacal dreams of our childhood. Growing up means knowing they cant be fulfilled. Growing up means gaining the wisdom and skills to get what we want within the limitations imposed by realitya reality which consists of diminished powers, restricted freedoms and, with the people we love, imperfect connections.”
—Judith Viorst (20th century)
“That all may be so, but when I begin to exercise that power I am not conscious of the power, but only of the limitations imposed on me.”
—William Howard Taft (18571930)