Niko is a variant of Nikos, which originates from the Greek Nikolaos which means 'victory of the people'. It is sometimes a nickname for the name Nicholas.
- Niko is a common Croat, Greek and Finnish name
- Niko is a musician currently signed to ATIC Records independent record label (formerly on Grand Central Records).
- Niko is a fictional character from the 1994 film The Mask, played by actor Orestes Matacena.
- Niko a fictional character from the television The Adventures of the Galaxy Rangers.
- Niko the Oyster is a character in the PC online game Insaniquarium.
- Niko, a radio personality for WNYZ-LP
- Niko Bellic, the protagonist and playable character of Grand Theft Auto IV.
- Niko Kovač, a Croatian soccer player.
- Niko Kranjčar, a Croatian soccer player.
- Niko Etxart, a Basque singer and musician.
- the Japanese name for the Chinese Fiddle, or Erhu.
- a fictional character played by Steven Seagal in the 1988 film, Above the Law.
- a performance alias used by Eurobeat artist Maurizio De Jorio.
- a wilderness Christian Leadership training program started by YWAM.
- brand of television monitor Niko Electronics Inc. (Apparently Out Of Business as of April 2008).
- Niklaren "Niko" Goldeye, a character in Tamora Pierce's "Emelan" books.
- Niko Ruud is the President of MLHS JSA
- Niko were a University rock band formed in Cardiff in 2002 composed of Mike Reed (Bass & Vocals), Simon Fisher (Guitar & Vocals) and Alex McGee (Drums & Vocals). After four years playing venues primarily in Cardiff, Leicester and London, Alex McGee left the band to take up a teaching appointment in Portugal.
- Niko Congiu is a Live Nation signed artist living in Cagliari, Italy.
- Niko is a common name amongst the Samoan people.
- Niko is a fictional character in the book "Shibumi" by Trevanian.
- Niko is a cosmetics company based in Toronto, Canada.
- Niko is the German Village Barber of Bryan Jasin
- Niko is a fictional pirate in some of the The Legend of Zelda video games.
- Niko Resources, a Canadian oil and gas company.