Major Intersections
| County | Location | Mile | km | Destinations | Notes |
|---|---|---|---|---|---|
| Wyoming |
Town of Gainesville | 0.00 | 0.00 | NY 19 | |
| Wethersfield | 6.67 | 10.73 | NY 362 | Northern terminus of NY 362 | |
| Java | 12.58 | 20.25 | NY 98 north | Eastern terminus of NY 78 / NY 98 overlap | |
| 15.19 | 24.45 | NY 77 south / NY 98 (Cattaraugus Road) | Hamlet of Java Center; western terminus of NY 78 / NY 98 overlap; southern terminus of NY 77 | ||
| Erie |
East Aurora | 27.77 | 44.69 | US 20A east (Big Tree Road) | Eastern terminus of US 20A / NY 78 overlap |
| 30.01 | 48.30 | NY 400 (Aurora Expressway) | Interchange | ||
| 30.76 | 49.50 | NY 16 south (Olean Road) | Eastern terminus of NY 16 / NY 78 overlap | ||
| 31.82 | 51.21 | US 20A west (Hamburg Street) | Western terminus of US 20A / NY 78 overlap | ||
| Elma | 34.87 | 56.12 | CR 574 (Jamison Road) | Former western terminus of NY 422 | |
| West Seneca | 37.36 | 60.13 | US 20 north (Transit Road) / NY 16 (Seneca Street) | Western terminus of NY 16 / NY 78 overlap; southern terminus of US 20 / NY 78 overlap | |
| 37.86 | 60.93 | NY 400 (Aurora Expressway) | Interchange | ||
| Cheektowaga | 39.65 | 63.81 | NY 354 (Clinton Street) | ||
| Depew | 42.55 | 68.48 | US 20 east / NY 130 (Broadway) | Northern terminus of US 20 / NY 78 overlap; eastern terminus of NY 130 | |
| Cheektowaga | 45.04 | 72.48 | NY 33 (Genesee Street) | ||
| 45.67 | 73.50 | I-90 / Thruway | Exit 49 (I-90 / Thruway) | ||
| Amherst | 46.94 | 75.54 | NY 5 (Main Street) | ||
| 47.92 | 77.12 | NY 324 (Sheridan Drive) | |||
| 54.99 | 88.50 | NY 263 (Millersport Highway) | Hamlet of Millersport; northern terminus of NY 263 | ||
| Niagara |
Town of Lockport | 58.45 | 94.07 | NY 93 (Robinson Road) | |
| City of Lockport | 60.93 | 98.06 | NY 31 (West Genesee Street / Walnut Street) | ||
| Newfane | 65.07 | 104.72 | NY 104 west (Ridge Road) | Hamlet of Wrights Corners; southern terminus of NY 78 / NY 104 overlap | |
| 65.38 | 105.22 | NY 104 east (Ridge Road) | Northern terminus of NY 78 / NY 104 overlap | ||
| Olcott | 73.49 | 118.27 | NY 18 (Lake Road) |
Read more about this topic: New York State Route 78
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