Muscular Dystrophy

Muscular dystrophy (MD) is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.

In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade, French neurologist Guillaume Duchenne gave a comprehensive account of thirteen boys with the most common and severe form of the disease, which now carries his name—Duchenne muscular dystrophy.

It soon became evident that the disease had more than one form. The other major forms are Becker, limb-girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and Emery-Dreifuss muscular dystrophy. These diseases predominately affect males, although females may be carriers of the disease gene. Most types of MD are multi-system disorders with manifestations in body systems including the heart, gastrointestinal system, nervous system, endocrine glands, eyes and brain.

Apart from the nine major types of muscular dystrophy listed above, several MD-like conditions have also been identified. Normal intellectual, behavioral, bowel and sexual function is noticed in individuals with other forms of MD and MD-like conditions. MD-affected individuals with susceptible intellectual impairment are diagnosed through molecular characteristics but not through problems associated with disability. However, a third of patients who are severely affected with DMD may have cognitive impairment, behavioral, vision and speech problems.

Read more about Muscular Dystrophy:  Signs and Symptoms, Cause, Diagnosis, Management, Prognosis, Types, Research Funding

Other articles related to "muscular dystrophy, dystrophy, muscular":

Myotilin
... and sarcolemmal proteins have been shown to result in muscular dystrophy and cardiomyopathy ... It is mutated in various forms of muscular dystrophy - Limb-Girdle Muscular Dystrophy type 1A (LGMD1A) - Myofibrillar Myopathy (MFM) - Spheroid Body Myopathy - Distal Myopathy Myotilin ... On the other hand, transgenic mice with mutated myotilin develop muscle dystrophy ...
Muscular Dystrophy - Research Funding
... the United States, the three primary federally funded organizations that focus on muscular dystrophy research (Gene therapy, Regenerative medicine) etc ... In 1966, the Muscular Dystrophy Association began its annual Jerry Lewis MDA Telethon, which has arguably done more to raise awareness of muscular ... Act to provide research for the various muscular dystrophies ...
LPGA State Farm Classic
... Originally known as the Jerry Lewis Muscular Dystrophy Golf Classic, the tournament was underwritten solely by the owners of The Rail Golf Course for its first ... Tournament names through the years 1976 Jerry Lewis Muscular Dystrophy Classic 1977 Rail Muscular Dystrophy Classic 1978–1992 Rail Charity (Golf) Classic 1993–2000 State Farm ...
Muscular Dystrophy Campaign Trailblazers
... Muscular Dystrophy Campaign Trailblazers is a UK wide network of young volunteers who campaign on issues that affect the lives of young people with muscular ...
Duchenne Muscular Dystrophy - Ongoing Research - Exon-skipping
... Patients with Becker's muscular dystrophy, which is milder than DMD, have a form of dystrophin which is functional even though it is shorter than ... noticed that a patient with mild Becker muscular dystrophy was lacking 46% of his coding region for dystrophin ... in cells removed from beta-thalassemia patients Wilton's group tested exon skipping for muscular dystrophy ...

Famous quotes containing the word muscular:

    Call the roller of big cigars,
    The muscular one, and bid him whip
    In kitchen cups concupiscent curds.
    Wallace Stevens (1879–1955)