Use
With MEME one can find similar biological functions and structures in different sequences. One has to take into account that the sequences variation can be significant and that the motifs are sometimes very small. It is also useful to take into account that the binding sites for proteins are very specific. This makes it easier to reduce wet-lab experiments (reduces costs and time). Indeed to better discover the motifs relevant from a biological point of view one has to carefully choose:
- The best width of motifs.
- The number of occurrences in each sequence.
- The composition of each motif.
Read more about this topic: Multiple EM For Motif Elicitation
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