MUC4

Mucin-4 cell surface associated (MUC4) is a mucin protein in humans that is encoded by the MUC4 gene. Like other mucins, Muc4 is a high-molecular weight glycoprotein, that has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. MUC4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation.