MLANA

MLANA

Identifiers Symbols MLANA; MART-1; MART1 External IDs OMIM: 605513 MGI: 108454 HomoloGene: 4026 GeneCards: MLANA Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• endoplasmic reticulum membrane • Golgi apparatus • trans-Golgi network • integral to plasma membrane • melanosome
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2315 77836 Ensembl ENSG00000120215 ENSMUSG00000024806 UniProt Q16655 Q2TA50 RefSeq (mRNA) NM_005511 NM_029993 RefSeq (protein) NP_005502 NP_084269 Location (UCSC) Chr 9:
5.89 – 5.91 Mb Chr 19:
29.7 – 29.71 Mb PubMed search

Protein melan-A also known as melanoma antigen recognized by T-cells 1 or MART-1 is a protein that in humans is encoded by the MLANA gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.