Mizuno may refer to:
- Mizuno Corp., a Japanese sportswear and sports equipment manufacturer
- Mizuno (daimyo), a political family in Japanese history
- Mizuno (aircraft manufacturer), a World War II aircraft manufacturer, see also Mizuno Shinryu
- Mizuno Shinryu, proposed rocket-powered kamikaze aircraft designed during WWII
- Mizuno experiment, a simple table-top experiment that appears to generate unexplained excess energy
- Asteroid 4541 Mizuno discovered by Yoshikane Mizuno
- Mizuno Classic, an annual golf tournament for professional female golfers on the United States LPGA Tour