Expression
MiR-17-92 cluster was identified to encode 6 single mature miRNA (miR-17, miR-19, miR-20, miR-92, miR-106) containing the first oncogenic miRNA.
MicroRNA from miR-19 family can be expressed from:
- * T-cell acute lymphoblastic leukemia
- * B-cell lymphomas
- * Cell lines
- * Cerebellum
- * Purkinje cells
- * HeLa cells
Finally they have tissues-specific miRNA expression. These microRNA are considered as oncogenes which improve proliferation, inhibits apoptosis and induce tumor angiogenesis.
These miRNA are context-specific and they have different roles depending on where they are.
Read more about this topic: Mir-19 Micro RNA Precursor Family
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