Reactions
| Reaction | Diagram | Enzyme |
| Acetyl-CoA (citric acid cycle) undergoes condensation with another acetyl-CoA subunit via Acetyl-CoA Transferase to form acetoacetyl-CoA | thiolase | |
| Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). | HMG-CoA synthase | |
| HMG-CoA is reduced to mevalonate by NADPH. This reaction occurs in the cytosol. It is the rate limiting step in cholesterol synthesis, which is why the enzyme catalyzing the reaction is a target of statins. | HMG-CoA reductase | |
| Mevalonate to 5-phosphomevalonate. | mevalonate kinase | |
| 5-phosphomevalonate to 5-pyrophosphomevalonate. | phosphomevalonate kinase | |
| Mevalonate-5-pyrophosphate to 3-isopentenyl pyrophosphate (IPP) (see also HIDS). |
|
mevalonate-5-pyrophosphate decarboxylase |
| 3-isopentenyl pyrophosphate is isomerized to dimethylallyl pyrophosphate. | isopentenyl pyrophosphate isomerase |
Read more about this topic: Mevalonate Pathway
Famous quotes containing the word reactions:
“Prolonged, indiscriminate reviewing of books is a quite exceptionally thankless, irritating and exhausting job. It not only involves praising trash but constantly inventing reactions towards books about which one has no spontaneous feeling whatever.”
—George Orwell (1903–1950)
“Cuteness in children is totally an adult perspective. The children themselves are unaware that the quality exists, let alone its desirability, until the reactions of grownups inform them.”
—Leontine Young (20th century)
“Separation anxiety is normal part of development, but individual reactions are partly explained by experience, that is, by how frequently children have been left in the care of others.... A mother who is never apart from her young child may be saying to him or her subliminally: “You are only safe when I’m with you.””
—Cathy Rindner Tempelsman (20th century)