Marcus Aemilius Lepidus may refer to:
- Marcus Aemilius Lepidus (consul 232 BC), consul in 232 BC and 221 BC, and augur
- Marcus Aemilius Lepidus (consul 187 BC), consul in 187 BC and 175 BC, Pontifex Maximus 180–152 BC, and censor
- Marcus Aemilius Lepidus (consul 158 BC), consul in 158 BC
- Marcus Aemilius Lepidus (consul 78 BC), consul in 78 BC
- Marcus Aemilius Lepidus (triumvir), son of the previous, part of the Second Triumvirate, consul in 46 BC and 42 BC, Pontifex Maximus 44–12 BC
- Lepidus the Younger, only son of Lepidus the triumvir and Junia Secunda (sister to Marcus Junius Brutus)
- Marcus Aemilius Lepidus (consul 6), consul in 6, general during the Illyrian War
- Marcus Aemilius Lepidus (executed 39), nephew of the above and brother-in-law to Emperor Caligula