Manfredi is a surname of Italian origin. The name refers to:
- Manfredi family of Faenza, Italy
- See Manfredi family
- Persons
- Antonio Manfredi (b. 1959), Spanish TV journalist
- Barbara Manfredi (1444–1466), Italian wife of Pino III Ordelaffi, lord of Forlì
- Bartolomeo Manfredi (1582–1622), Italian painter; a leading member of the Caravaggisti
- Christopher Manfredi (contemporary), Canadian professor of political science
- Ercole Manfredi (1883–1973), Italian architect who worked in Siam/Thailand
- Juan J. Manfredi (b. 1957), Mathematician
- Laurence Manfredi (b. 1974), French Olympic shot putter
- Nino Manfredi (1921–2004), Italian actor
- Raphael Manfredi (b. 1968), French software engineer
- Valerio Massimo Manfredi (b. 1946), Italian architect and historian
- Fictional characters
- Kate Manfredi, character in the Australian television series McLeod's Daughters
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