Anatomy
It can be divided into five parts:
- Thin descending limb of loop of Henle
- The thin descending limb has low permeability to ions and urea, while being highly permeable to water. The loop has a sharp bend in the renal medulla going from descending to ascending thin limb.
- Thin ascending limb of loop of Henle
- The thin ascending limb is not permeable to water, but it is permeable to ions.
- Thick ascending limb of loop of Henle
- Sodium (Na+), potassium (K+) and chloride (Cl-) ions are reabsorbed from the urine by secondary active transport by the Na-K-2Cl symporter (NKCC2). The electrical and concentration gradient drives more reabsorption of Na+, as well as other cations such as magnesium (Mg2+) and importantly calcium (Ca2+).
- Cortical thick ascending limb—The cortical thick ascending limb drains urine into the distal convoluted tubule.
Read more about this topic: Loop Of Henle
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