Henle can refer to:
- Friedrich Gustav Jakob Henle, a German physician, pathologist and anatomist, discoverer of the "loop of Henle" in the kidney
- Fritz Henle, a photographer, known as "Mr. Rollei" for his use of the 2.25" square format film used in the Rolleiflex camera
- G. Henle Verlag, German publishing house of sheetmusic
- Moritz Henle, a German composer
- Robert A. Henle, an American electrical engineer
- Robert J. Henle, the 46th President of Georgetown University