Local Anesthetics in Clinical Use
Esters are prone to producing allergic reactions, which may necessitate the use of an Amide. The names of each locally clinical anesthetic have the suffix "-caine". In general Amides have two "i"'s in their nomenclature while the Esters only have one.
Most ester local anesthetics are metabolized by pseudocholinesterases, while amide local anesthetics are metabolized in the liver. This can be a factor in choosing an agent in patients with liver failure.
Read more about this topic: Local Anesthetic
Famous quotes containing the word local:
“Surely there must be some way to find a husband or, for that matter, merely an escort, without sacrificing one’s privacy, self-respect, and interior decorating scheme. For example, men could be imported from the developing countries, many parts of which are suffering from a man excess, at least in relation to local food supply.”
—Barbara Ehrenreich (b. 1941)