Local Anesthetics in Clinical Use
Esters are prone to producing allergic reactions, which may necessitate the use of an Amide. The names of each locally clinical anesthetic have the suffix "-caine". In general Amides have two "i"'s in their nomenclature while the Esters only have one.
Most ester local anesthetics are metabolized by pseudocholinesterases, while amide local anesthetics are metabolized in the liver. This can be a factor in choosing an agent in patients with liver failure.
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Famous quotes containing the word local:
“The local is a shabby thing. There’s nothing worse than bringing us back down to our own little corner, our own territory, the radiant promiscuity of the face to face. A culture which has taken the risk of the universal, must perish by the universal.”
—Jean Baudrillard (b. 1929)