Loading Dose - Calculating The Loading Dose

Calculating The Loading Dose

Four variables are used to calculate the loading dose:

Cp = desired peak concentration of drug
Vd = volume of distribution of drug in body
F = bioavailability
S = salt fraction

The required loading dose may then be calculated as

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

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