Acute
Acute liver failure is defined as "the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes (encephalopathy) in a patient without known prior liver disease".:1557
The diagnosis of acute liver failure is based on physical exam, laboratory findings, patient history, and past medical history to establish mental status changes, coagulopathy, rapidity of onset, and absence of known prior liver disease respectively.:1557
The exact definition of "rapid" is somewhat questionable, and different sub-divisions exist which are based on the time from onset of first hepatic symptoms to onset of encephalopathy. One scheme defines "acute hepatic failure" as the development of encephalopathy within 26 weeks of the onset of any hepatic symptoms. This is sub-divided into "fulminant hepatic failure", which requires onset of encephalopathy within 8 weeks, and "subfulminant", which describes onset of encephalopathy after 8 weeks but before 26 weeks. Another scheme defines "hyperacute" as onset within 7 days, "acute" as onset between 7 and 28 days, and "subacute" as onset between 28 days and 24 weeks.:1557
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Famous quotes containing the word acute:
“Long before I wrote stories, I listened for stories. Listening for them is something more acute than listening to them. I suppose it’s an early form of participation in what goes on. Listening children know stories are there. When their elders sit and begin, children are just waiting and hoping for one to come out, like a mouse from its hole.”
—Eudora Welty (b. 1909)
“The talk shows are stuffed full of sufferers who have regained their health—congressmen who suffered through a serious spell of boozing and skirt-chasing, White House aides who were stricken cruelly with overweening ambition, movie stars and baseball players who came down with acute cases of wanting to trash hotel rooms while under the influence of recreational drugs. Most of them have found God, or at least a publisher.”
—Calvin Trillin (b. 1935)
“I find the pain of a little censure, even when it is unfounded, is more acute than the pleasure of much praise.”
—Thomas Jefferson (1743–1826)