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- Sailor Moon (see List of Sailor Moon video games)
- Saikano (Not yet released but sources state, "It will likely be released on PSP and PS2")
- Saint Seiya (see main article)
- Sakigake!! Otokojuku (Game Boy, Family Computer, PlayStation, PlayStation 2)
- Sands of Destruction (DS)
- Science Ninja Team Gatchaman (Atari ST, Amiga, Amstrad CPC, Commodore 64, ZX Spectrum, PC-98, PlayStation, PlayStation 2)
- Samurai Champloo: Sidetracked (PlayStation 2)
- Samurai Deeper Kyo (GBA)
- Samurai 7 (PlayStation 2)
- School Rumble (PlayStation 2)
- School Rumble: Ane san Jikan Desu (PSP)
- Serial Experiments Lain (PlayStation)
- Shaman King (Game Boy Advance)
- Shaman King (PlayStation 2)
- Shin Raki Suta Moe Doriru Tabidachi
- Shin Lucky Star Moe Drill
- Shin Lucky Star Moe Drill Tabidachi
- Shijou Saikyou no Deshi Kenichi(PS2)
- Shogo: Mobile Armor Division (PC)
- Shojo Kakumei Utena (Sega Saturn)
- Skip Beat (PlayStation 2) (Japan Only)
- Soar High! Isami
- Sora no Otoshimono Forte: Dreamy Season (Nintendo DS)
- Soul Eater: Monotone Princess (Nintendo Wii)
- Soul Eater: Plot of Medusa (Nintendo DS)
- Soul Eater: Battle Resonance (PlayStation 2, PSP)
- Sotsugyou (video game) and Sotsugyou M
- Spriggan: Lunar Verse (PlayStation)
- Sukisho! (PC, PlayStation 2)
- Super Bikkuriman (Super Famicom)
- Sutobasu YarÅ Show (Super Famicom)
- Episode 1: Suki na Mono wa Suki Dakara Shouganai!! -FIRST LIMIT- (PC, PlayStation 2)
- Episode 2: Suki na Mono wa Suki Dakara Shouganai!! -TARGET NIGHTS- (PC, PlayStation 2)
- Episode 3: Suki na Mono wa Suki Dakara Shouganai!! -RAIN- (PC, PlayStation 2)
- Episode 4: Suki na Mono wa Suki Dakara Shouganai!! +White Flower+ (PC)
- Sword of the Berserk: Guts' Rage
- Sword Art Online:Infinite Moment
Read more about this topic: List Of Video Games Based On Anime Or Manga