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- James D. La Belle (1924–1945) – sailor
- Rob LaBelle – character actor
- Manuel Lagos (born 1971) – soccer player
- Ann Landers – (1918–2002) columnist for Minneapolis Star Tribune; birth name Eppie Lederer
- Lenny Lane (born 1970) – wrestler
- Odin Langen (1913–1976) – member of U.S. Congress
- Jessica Lange (born 1949) – actor
- Jim Lange (born 1933) – television host
- Jamie Langenbrunner (born 1975) – hockey player
- Josh Langfeld (born 1977) – hockey player
- Katherine Lanpher (born 1959) – radio personality, journalist
- Gene Larkin (born 1962) – baseball player
- Erik Larsen (born 1962) – comic-book writer, artist, and publisher
- Gary Larsen (born 1942) – football player
- Oscar Larson § (1871–1957) – member of U.S. Congress
- Reed Larson (born 1956) – hockey player
- George Latimer § (born 1935) – politician
- Roger Laufenburger (1921–2001) – politician, radio announcer, insurance agent
- Tom Laughlin (born 1931) – actor
- Trevor Laws § (born 1985) – football player
- Matt Lawton § (born 1971) – baseball player
- Bernie Leadon (born 1947) – musician
- Carrie Lee – beauty queen
- Carl Lee – football player
- Tammy Lee (born 1971) – businessperson and politician
- Pinky Lee (1907–1993) – noted actor and star of The Pinky Lee Show
- James LeGros (born 1962) – actor
- Tom Lehman (born 1959) – golfer
- John D. LeMay (born 1962) – actor
- Greg LeMond (born 1961) – Tour de France winner
- Brock Lesnar § (born 1977) – wrestler
- Meridel Le Sueur § (1900–1996) – writer
- Jon Leuer (born 1989) – basketball player for the Milwaukee Bucks
- Harold LeVander § (1910–1992) – 32nd Governor of Minnesota
- David Levin – singer-songwriter
- Mark LeVoir (born 1982) – offensive tackle for the New England Patriots
- Bob Lewis (1924–2006) – businessperson, champion race horse owner
- Sinclair Lewis (1885–1951) – Nobel Prize-winning novelist
- Terry Lewis § (born 1956) – songwriter, co-founder of Flyte Tyme Productions
- Walter Liggett (1886–1935) – journalist, newspaper editor
- C. Walton Lillehei (1918–1999) – doctor who performed first open heart surgery
- John Lind § (1854–1930) – 14th Governor of Minnesota; member of U.S. Congress
- Gottfrid Lindsten 29th Lieutenant Governor of Minnesota
- Terrance Lindall (born 1944) – artist
- Charles August Lindbergh, Sr. § (1859–1924) – member of U.S. Congress
- Charles Lindbergh § (1902–1974) – aviator, first non-stop solo flight across the Atlantic Ocean
- Chris Liwienski – football player
- Charles M. Loring (1833–1922) – Minneapolis businessman, civic leader, "Father of Park System"
- Maud Hart Lovelace (1892–1980) – author
- Kirk Lowdermilk – football player
- Cal Ludeman (born 1951) – politician, state commissioner, farmer
- Ernest Lundeen § (1878–1940) – U.S. Senator; member of U.S. Congress
- Bob Lurtsema – football player
- Bill Luther (born 1945) – member of U.S. Congress
- David Lykken (1928–2006) – behavioral geneticist and Professor Emeritus of Psychology and Psychiatry
- Joseph Lykken (born 1957) – physicist
- Dorothy Lyman (born 1947) – actor, director, and producer
- Kelly Lynch (born 1959) – actor
- Audra Lynn (born 1980) – model and actor
- Jerry Lynn (born 1963) – wrestler
Read more about this topic: List Of People From Minnesota