S
- José Saenz – 492nd fugitive on the list of FBI Ten Most Wanted Fugitives
- Katey Sagal – actress
- Susan Saint James – actress
- Jim Salsbury – professional football player
- Catherine Sandoval – Public utilities commissioner, law professor, Rhodes scholar
- Jay Sandrich – film director, film producer
- Dick Sargent – actor
- William Schallert – actor
- Emily Schulman – actress
- Geoff Schwartz – NFL football player
- Jason Schwartzman – actor, musician
- Melody Thomas Scott – actress
- Eugene Selznick – Hall of Fame volleyball player
- Karen Sharpe - former actress, wife of director/producer Stanley Kramer
- Harry Shearer – actor, comedian, musician, composer
- Brad Sherman – congressman
- Larry Sherry – major league baseball 1959 World Series MVP
- Mike Shinoda – musician
- Joel Siegel – film critic
- James Sikking – actor
- Jonathan Silverman – actor
- John Singleton – film director, writer, film producer
- Slash – Guns N' Roses and Velvet Revolver guitarist
- Leonard Slatkin – conductor
- Erika Slezak – actress
- Duke Snider – professional baseball player
- Ron Spears – professional football player
- Tori Spelling – actress
- Robert Stack – actor
- Brett Sterling – NHL ice hockey player
- Adlai Stevenson II – politician
- Colonel Earl Reginald Stevenson, Colonel Aide de Camp, Governors to Tennessee, Kentucky, Alabama and New Mexico
- Kristen Stewart – actress
- Michelle Stith – President, Church of Scientology in Los Angeles
- Jill St. John – actress
- Dean Stockwell – actor
- Madeleine Stowe – actress
- Darryl Strawberry – professional baseball player
- Jeff Stryker – pornographic film actor
- Cree Summer – actress
- Dale Swann – character actor
- Earl Sweatshirt - rapper. Member of OFWGKTA
Kristen Stewart- actress
Read more about this topic: List Of People From Los Angeles