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- Rockne S. O'Bannon – film director, writer, film producer
- John O'Brien – football player
- Ryan O'Neal – actor
- Tatum O'Neal – actress
- Bob Ojeda – baseball player
- Masi Oka – actor on NBC's Heroes
- Barret Oliver – actor and photographer
- Edward James Olmos – actor, writer, film producer, film director
- Mary-Kate and Ashley Olsen – actresses
- Haley Joel Osment – actor
- Emily Osment – actress
Read more about this topic: List Of People From Los Angeles