Recent Studies
Mortality in relation to smoking: 50 years' observation on male British doctors
- Authors: R. Doll, R. Peto, J. Boreham, I. Sutherland
- Publication data: BMJ 2004;328:1519–33.
- Description: This is the British doctors study. A prospective clinical trial which ran from 1951 to 2001, and in 1956 provided convincing statistical evidence that tobacco smoking increases the risk of lung cancer.
- Importance: Impact
Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study
- Authors: The Scandinavian Simvastatin Survival Study Group.
- Publication data: Lancet 1994;344:1383–1389
- Description: The Scandinavian Simvastatin Survival Study (also known under the abbreviation 4S) is a multicenter clinical trial that was performed in the 1990s in Scandinavia. The objective of the study was to assess the effect of a cholesterol-lowering drug called simvastatin on mortality and morbidity in group of 4444 patients with coronary heart disease, aged between 35 and 70 years. The patients presented with moderate hypercholesterolemia between 5.5 and 8.0 mmol/L. The results of the trial showed that simvastatin had a lowering effect on mortality and morbidity of patients suffering from coronary heart disease.
- Importance: Impact
Heart Protection Study
- Authors: Medical Research Council
- Online version: Research site
- Description: The Heart Protection Study is a large randomized controlled trial by the Medical Research Council (MRC) in the United Kingdom. It studies the use of statin (simvastatin 40 mg) medication and vitamin supplementation (vitamin E, vitamin C and beta carotene) in patients that are at risk for cardiovascular disease.
- Importance: Impact
Read more about this topic: List Of Important Publications In Medicine
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