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Calvin Samson
- Tom Clancy's Splinter Cell: Conviction
- Vice President under President Patricia Caldwell
- In reality was a terrorist double agent who took an active role in the Third Echelon conspiracy aiming to assassinate the President so that he could assume power.
- Shot by rogue agent Sam Fisher and left for the authorities.
James Sandecker
- Clive Cussler's Dirk Pitt novels
- Former Head of NUMA (National Underwater and Marine Agency).
- Vice President to President Ward when the Vice President suddenly died in office.
Bud Sauer
- Phi Kappa Sigma's West Wing: Frat Life
- Vice President to Alfred Victor DuPont
- Party: Conservative Republican
- Scudwise Gamgi - Shredder Extraordinaire
Paul Saxon
- Shadow Conspiracy (1997 film)
- Plotted to kill President Manchester and take his place, but was accidentally killed during the assassination attempt.
- Played by: Ben Gazzara
Cletus Spuckler
- The Simpsons "Future-Drama" episode
- A native of Springfield, Delroy becomes Vice President at an unspecified future date.
- Is invited to attend the funeral of the Sultan of Brunei.
Greg Stillson
- Vice President in The Dead Zone, based on the novel by Stephen King
- Seen in a vision by Johnny Smith as succeeding to the White House and causing Armageddon.
- The series ended before Stillson sought White House.
- Played by Sean Patrick Flanery
- Also portrayed in the movie version by Martin Sheen, although he remained an unsuccessful Senate Candidate.
Strock
- Vice President in: The General's President by John Dalmas
- Served as Vice President to President Donnelly.
- Forced by Donnelly to resign after a scandal.
Dan Sullivan
- Moonfall by Jack McDevitt
- Is briefly mentioned in the novel as almost succeeding to the presidency after President Wes Hamlin nearly resigns following an assassination attempt that left him paralyzed from the waist down.
- Convinced President Hamlin not to resign.
- Former senator from Georgia.
- Party: Republican
June Syers
- The Kid Who Ran For President (1996 children's book by Dan Gutman)
- Vice president under Judson Moon, who was the youngest American president at age thirteen.
- Elected on the "Moon and June" ticket in 2000.
- Became the first African American and female president after President Moon resigned in 2002.
Read more about this topic: List Of Fictional Vice Presidents Of The United States