S
- Sabotage
- Sammy Lightfoot
- Saracen
- Sargon and Sargon II
- Sea Dragon (port)
- Secret Agent: Mission One
- Serpentine
- The Seven Cities of Gold (port)
- Shamus (port)
- Shard of Spring
- Sherlock Holmes: Another Bow
- Sherwood Forest
- Shogun
- Sid Meier's Pirates! (port)
- Silent Service
- Situation Critical
- "Ski crazed"
- Skyfox
- Snack Attack
- Snack Attack II
- Snake Byte
- Sneakers
- Snoopy to the Rescue
- Softporn Adventure
- Sokoban
- Southern Command
- Space
- Space II
- Space Defender
- Space Eggs
- Space Quarks
- Space Quest
- Space Quest II: Vohaul's Revenge
- Space Vikings
- Spare Change
- Speedway Classic
- Spellevator
- Spellicopter
- Spider-Man
- Spindizzy
- Spy Hunter (port)
- Spy's Demise
- Spy vs. Spy series
- Standing Stones
- Star Blazer
- Star Thief (computer game)
- Star Trek: Strategic Operations Simulator (port)
- Star Trek: The Kobayashi Alternative
- Starship Commander
- Stationfall
- Stellar 7
- Strange Odyssey (Scott Adams #6)
- Strike Fleet Naval Simulation game
- Summer Games (port)
- SunDog: Frozen Legacy
- Super Bunny
- Speedway Classics
- Suspended
- Swashbuckler
- Sword of Kadash
- SwordThrust
- Syzygy
Read more about this topic: List Of Apple II Games