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- Elsa Lanchester as Mary Shelley and The Monster's Mate in Bride of Frankenstein (1935)
- Stan Laurel as Himself and Alf Laurel in Our Relations (1935)
- Joey Lawrence as Ralph Bitondo and Ricky Prince in Prince For A Day, 1995 TV Movie.
- Jason Lee as Brodie Bruce and Banky Edwards in Jay & Silent Bob Strike Back (2001)
- Jason Lee as Dennis Pepper and Steve in A Better Place (1997)
- Jack Lemmon as Professor Fate and Prince Hapnik in The Great Race (1965)
- Jerry Lewis as Professor Julius Kelp and Buddy Love and Baby Kelp in The Nutty Professor (1963)
- Jerry Lewis as Willard Woodward, James Peyton, Everett Peyton, Julius Peyton, Captain Eddie Peyton, Skylock Peyton, and 'Bugs' Peyton in The Family Jewels (1965)
- Jerry Lewis as Gerald Clamson and Syd Valentine in "The Big Mouth" (1967)
- Lindsay Lohan as Hallie Parker and Annie James in The Parent Trap (1998)
- Lindsay Lohan as Aubrey Fleming and Dakota Moss in I Know Who Killed Me (2007)
- John Lund as Captain Bart Cosgrove and his son, Lieutenant Gregory Piersen, in To Each His Own (1946)
Read more about this topic: List Of Actors Who Have Played Multiple Roles In The Same Film