In Computing
- Lis (linear algebra library), Library of Iterative Solvers for linear systems
- LIS programming language
- Language-independent specification, a programming language specification providing a common interface usable for defining semantics applicable to arbitrary programming language bindings
- Local information systems, Information systems that systematically collects, processes, stores and disseminates intelligence about small geographic areas e.g. local neighbourhoods, for policymakers, citizens and others
- Location Information Server, a server that provides location information, either in the form of geographic location or a street address
- Logical IP subnetwork, a group of nodes sharing a common subnet in an ATM network
- an implementation of STREAMS for Linux
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