History
In 2004, the US FDA announced that there is a need for increased product development involving biomarkers and surrogate markers. In particular, there has been intense research regarding the use of the NGAL biomarker.
The first study conducted to determine if NGAL is effective as a biomarker was published in July 2011. The study found that the treatment with fenoldopam decreases urinary NGAL significantly after cardiac surgery. This suggests that fenoldopam has nephroprotective effects.This study was important in defining NGALs role in AKI.
In the Philippines, the first guideline implementation of NGAL as a diagnostic biomarker occurred in 2010 for the detection of AKI in leptospirosis management.
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