Layne is a surname, and may refer to:
- Bernice Layne
- Bobby Layne
- David Layne
- Jerry Layne
- Kenny Layne
- Lancelot Layne
- Oscar Willis Layne
- Shontelle Layne
- Tamirat Layne
Layne is also a first name, and may refer to:
- Layne Beachley, seven time women's surf World Champion
- Layne Flack, poker professional
- Layne Staley, deceased lead singer of Alice in Chains
- Layne Abeley, character from Lisi Harrison's The Clique Series.