Killer Yeast - Kluyveromyces Lactis

Kluyveromyces Lactis

Killer properties of Kluyveromyces lactis are associated with linear DNA plasmids, which have on their 5'end associated proteins, which enable them to replicate themselves, in way similar to adenoviruses. It's an example of protein priming in DNA replication. MAK genes are not known. The toxin consists of three subunits, which are matured in golgi complex by signal peptidase and glycosylated.

The mechanism of action is poorly understood. Affected cells are arrested in G1 phase and lose viability.

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