Khamsa (Arabic/Persian, lit. "five") may refer to:
- Hamsa, a popular amulet in the Middle East and North Africa, also romanized as khamsa
- Al Khamsa, a bloodline for Arabian horses that traces back to five mares
- Al Khamsa (organization), a nonprofit organization in the United States that supports the breeding of Al Khamsa bloodline horses
- Khamseh, a tribal people of Iran
- Khamsa (film), a 2008 film