IQGAP1

IQGAP1

Identifiers Symbols IQGAP1; HUMORFA01; SAR1; p195 External IDs OMIM: 603379 MGI: 1352757 HomoloGene: 74514 GeneCards: IQGAP1 Gene

Gene Ontology
Molecular function	• GTPase inhibitor activity • GTPase activator activity • Ras GTPase activator activity • calcium ion binding • protein binding • calmodulin binding • protein kinase binding • protein phosphatase binding • Rac GTPase binding
Cellular component	• nucleus • nucleolus • cytoplasm • microtubule • actin filament • plasma membrane • lateral plasma membrane • cell junction • midbody • ribonucleoprotein complex • cell leading edge • slit diaphragm • neuron projection
Biological process	• regulation of cytokine production • energy reserve metabolic process • signal transduction • small GTPase mediated signal transduction • negative regulation of dephosphorylation • positive regulation of GTPase activity • small molecule metabolic process • positive regulation of protein kinase activity • regulation of insulin secretion • cellular response to calcium ion • glomerular visceral epithelial cell development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8826 29875 Ensembl ENSG00000140575 ENSMUSG00000030536 UniProt P46940 Q9JKF1 RefSeq (mRNA) NM_003870 NM_016721 RefSeq (protein) NP_003861 NP_057930 Location (UCSC) Chr 15:
90.93 – 91.05 Mb Chr 7:
80.71 – 80.8 Mb PubMed search

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.