Disease Associations
α-internexin has also been implicated in several degenerative diseases such as Amyotrophic lateral sclerosis, dementia with Lewy bodies, Parkinson’s Disease, neuropathies, tropical spastic paraparesis and HTLV-1 associated myelopathy. In HTLV-1 myelopathy, Tax, transactivator expressed by HTLV-1, interacts with α-internexin in cell culture resulting in dramatic reduction in Tax transcactivation and intermediate filament formation.
Read more about this topic: Internexin
Famous quotes containing the words disease and/or associations:
“Narcissist: psychoanalytic term for the person who loves himself more than his analyst; considered to be the manifestation of a dire mental disease whose successful treatment depends on the patient learning to love the analyst more and himself less.”
—Thomas Szasz (b. 1920)
“Wild as it was, it was hard for me to get rid of the associations of the settlements. Any steady and monotonous sound, to which I did not distinctly attend, passed for a sound of human industry.... Our minds anywhere, when left to themselves, are always thus busily drawing conclusions from false premises.”
—Henry David Thoreau (1817–1862)