Disease Associations
α-internexin has also been implicated in several degenerative diseases such as Amyotrophic lateral sclerosis, dementia with Lewy bodies, Parkinson’s Disease, neuropathies, tropical spastic paraparesis and HTLV-1 associated myelopathy. In HTLV-1 myelopathy, Tax, transactivator expressed by HTLV-1, interacts with α-internexin in cell culture resulting in dramatic reduction in Tax transcactivation and intermediate filament formation.
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