HSG may refer to:
- University of St. Gallen
- Handling Stolen Goods
- Hysterosalpingography
- High Sierra Group, the creators of the High Sierra Format
- IATA airport code for Saga Airport in Kawasoe, Saga Prefecture, Japan.
- Hathersage railway station, England; National Rail station code HSG.
- HSG Wetzlar, Handballspielgemeinschaft Wetzlar, german team handball Bundesliga club.