HSE may mean:
- Health Survey for England
- Higher Speed Ethernet - technology term
- Health and Safety Executive, United Kingdom
- Health Service Executive, Ireland
- Health, Safety and Environment - business term
- Helsinki School of Economics, Finland - business university
- Helsinki Stock Exchange, Finland - financial exchange
- National Research University - Higher School of Economics based in Moscow, Russia
- Hamilton Southeastern Schools - a public school district in Fishers, Indiana
- Hamilton Southeastern High School - one of the school district's two high schools
- Hybrid search engine - computer science
- Hydrostatic equilibrium - Physics term
- A trim level for the Land Rover brand vehicles
- Holding Slovenske elektrarne, a power generation company in Slovenia
- Herpes simplex encephalitis, medical term
- Harmony School of Excellence, a charter school found in Houston, Texas that is part of the Cosmos Foundation