HRS may refer to:
- Copenhagen Hospitality College (Danish: Hotel og Restaurantskolen), a vocational college located in Copenhagen, Denmark
- Head-Royce School, Oakland, California
- Health and Retirement Study, conducted by the Institute for Social Research at the University of Michigan in Ann Arbor
- Heart Rhythm Society, an international non-profit organization that promotes education and advocacy for cardiac arrhythmia professionals and patients
- Helena Romanes School and Sixth Form Centre, Essex, England
- Hepatorenal syndrome, a life-threatening medical condition that consists of rapid deterioration in kidney function in individuals with cirrhosis or fulminant liver failure
- High Resolution Spectrograph, a spectrograph installed on the Hubble Space Telescope
- Historical Records Survey, a project of the Works Progress Administration New Deal program in the United States
- House Rabbit Society, an American non-profit activist organization that rescues and adopts rabbits
- Hrvatski Radioamaterski Savez, a national non-profit organization for amateur radio enthusiasts in Croatia
- Hunt Retribution Squad, a name used by militant animal rights activists that are willing to inflict harm on those involved in blood sport
- Sikorsky H-19, a multi-purpose helicopter designated HRS by the United States Marine Corps
- Hot rolled steel, a product of hot rolling, a metalworking process that occurs above the recrystallization temperature of the material
- Hyper Rayleigh scattering, the elastic scattering of light by particles much smaller than the wavelength of the light
- Human Rights Service, a Norwegian conservative think tank